陈茁

所属学科

基础医学-病理学

职称、职务

副教授，硕士研究生导师

E-mail

chenzhuo@whu.edu.cn

研究方向

1抗脑胶质瘤药物药理

2.感染与免疫

个人简介

陈茁，博士，硕士研究生导师，楚天学子。发表SCI收录30余篇，参与编写专著2本，获国家发明专利4项。主持国家自然科学基金2项、湖北省自然科学基金2项。

代表作（五年内）

1.Zhuo Chen, Wenzi Zhang, Danni Wang, Ruiqin Luo, Yuexin Yao, Xiaoyang Tao, Lu Li, Qin Pan, and Xiaoming Sun. CD44 is a macrophage receptor for TcdB from Clostridioides difficile that via its lysine-158 succinylation contributes to inflammation.Gut Microbes. 2025, 17, 2506192.（第一作者）

2.Chen Z, Yao Y, Luo R, Xia X, Wang D, Li C, Sun X. A visual isothermal platform for the rapid detection of Clostridioides difficile in fecal using locked nucleic acid-modified split DNAzyme probes facilitated by recombinase polymerase amplification.Sens Actuators B Chem. 2025, 443: 138312.（第一作者）

3. Xiaoming Sun, Danni Wang, Yani Chen, Xiaoming Zheng, Wenzi Zhang, Zhihua Ruan,Zhuo Chen. The dual effects of propofol down-regulating PD-L1 expression and inhibiting autophagy to reduce cerebral ischemia reperfusion injury. Int Immunopharmacol. 2025 Mar 29;154:114548.（通讯作者）

4. Ruiqin Luo, Yuexin Yao,Zhuo Chen, Xiaoming Sun. An examination of the LPS-TLR4 immune response through the analysis of molecular structures and protein-protein interactions.Cell Communication and Signaling.2025 Mar 18;23(1):142.（共同通讯作者）

5. Sun X, Zhang W, Gou C, Wang X, Wang X, Shao X, Chen X,Chen Z. AS1411 binds to nucleolin via its parallel structure and disrupts the exos-miRNA-27a-mediated reciprocal activation loop between glioma and astrocytes. Biochim Biophys Acta Mol Basis Dis. 2024 Jun;1870(5):167211.（通讯作者）