钦闪闪

所属学科

基础医学-生物化学

职称、职务

教授，硕士研究生导师

E-mail

qinss77@163.com

研究方向

1.肿瘤发病机制与分子靶向治疗

2.EMT与肿瘤微环境可塑性调控机理

个人简介

钦闪闪，博士，教授，硕士研究生导师，湖北省政府专项津贴专家、国家自然科学基金委函评专家，入选湖北省医学青年拔尖人才（第一层次）、十堰市青年科技领军人才等高层次人才计划。

近5年以第一/通讯（含共同）作者发表中科院二区及以上高水平SCI论文20余篇（含Science Advances等国际顶级期刊）。此外，参与编写学术专著1部，申请国家发明专利10项，已获授权1项。主持国家自然科学基金面上项目及青年科学基金项目各1项。

代表作（五年内）

1.Wang Jing^#, Li Dandan^#, Zhai Lantian, Yuan Lin, Zha Yiwei, Zhang Xiangang, He Yanling, Qin Shanshan. Transcobalamin 1 is a keratinocyte-derived autoantigen driving psoriasis through T helper 17 cell activation.Sci Adv. 2026 Apr 24;12(17):eadv6716.

2. Li Dandan^#, Zhou Zeng^#, Hui Yuanjian, Yu Hedong, Ren Tao, Zhai Lantian, Yuan Lin, Xia Lingyun, Leng Weidong*,Qin Shanshan*: EHBMT, a method for visualizing tumor evolution, identifies a surge in gastric cancer with hybrid epithelial–mesenchymal phenotypes due to an inflammatory microenvironment.Exp Mol Med. 2025, 57(11):2440-2457.

3.Li Dandan^#, Zhou Zeng^#, Li Xinqi^#, Guo Qiwei, Yuan Lin, Zhang Xiangang, Zhai Lantian, Xia Lingyun, Leng Weidong*,Qin Shanshan*: Hypermethylation-mediated HNF4A silencing by Helicobacter pylori infection drives gastric cancer by disrupting epithelial cell polarity and activating EMT signaling.Cell Death & Disease. 2025, 16(1): 643.

4.Qin Shanshan*, Liu Yue, Zhang Xiangang, Huang Pan, Xia Lingyun, Leng Weidong*, Li Dandan*: lncRNA FGD5-AS1 is required for gastric cancer proliferation by inhibiting cell senescence and ROS production via stabilizing YBX1.Journal of Experimental & Clinical Cancer Research. 2024, 43(1):188.

5.Qin Shanshan*, Guo Qiwei, Liu Yue, Zhang Xiangang, Huang Pan, Yu Hedong, Xia Lingyun, Leng Weidong*, Li Dandan*: A novel TGFbeta/TGILR axis mediates crosstalk between cancer-associated fibroblasts and tumor cells to drive gastric cancer progression.Cell Death & Disease. 2024, 15(5):368.

6.Li Dandan^#, Shen Li^#, Zhang Xudong, Chen Zhen, Huang Pan, Huang Congcong,Qin Shanshan*. LncRNA ELF3-AS1 inhibits gastric cancer by forming a negative feedback loop with SNAI2 and regulates ELF3 mRNA stability via interacting with ILF2/ILF3 complex.Journal of Experimental & Clinical Cancer Research, 2022, 41(1):332.

7.Li Dandan, Xu Mengjie, Wang Zidi, Huang Congcong, Chen Zhen, Tang Gaijuan, Zhu Xingji, Cai Mengyu,Qin Shanshan*: The EMT-induced lncRNA NR2F1-AS1 positively modulates NR2F1 expression and drives gastric cancer via miR-29a-3p/VAMP7 axis.Cell Death & Disease, 2022, 13(1): 84.

8.Li Dandan, She Jiajun, Hu Xinhui, Zhang Meixin, Sun Ruonan,Qin Shanshan*. The ELF3-regulated lncRNA UBE2CP3 is over-stabilized by RNA-RNA interactions and drives gastric cancer metastasis via miR-138-5p/ITGA2 axis.Oncogene, 2021, 40: 5403-5415.